Zetesis Scientific Due Diligence

Run Zetesis's graded reading of a scientific, biomedical, clinical, or AI/ML claim. Grades each evidence dimension and returns an overall reading, with every source cited by hard public id (PMID, DOI, NCT, NIH grant, SEC filing). Covers drug, omics, target-validation, diagnostic, and AI-model claims. Runs the hosted engine end to end and typically takes a couple of minutes, long enough that some clients background or time out the call. The output is Zetesis's own reading as a finished artifact. zetesis_scope and zetesis_evidence return the same dated sources and the same grading rubric immediately and without running a model, at full source depth rather than abstract level. A signed, independently re-checkable dossier is available by request at the Zetesis site. Args: claim: the claim to evaluate, in one or two sentences. context: optional background (stage, field, the decision at hand). documents: optional source text (a deck, abstract, or paper). as_of: year the claim was made. Set it for any claim that is not brand new. It restricts evidence to what existed then, which both keeps later outcomes out of the reading and sharply improves what is retrieved: left open, a pivotal trial report competes with every paper published since and gets buried.

{
  "type": "object",
  "properties": {
    "claim": {
      "description": "The claim to evaluate, in one or two sentences.",
      "title": "Claim",
      "type": "string"
    },
    "context": {
      "default": "",
      "description": "Optional background: stage, field, or the decision at hand.",
      "title": "Context",
      "type": "string"
    },
    "documents": {
      "default": "",
      "description": "Optional source text to evaluate against, such as a deck, abstract or paper.",
      "title": "Documents",
      "type": "string"
    },
    "as_of": {
      "default": 0,
      "description": "Year the claim was made. Set it for any claim that is not brand new: it restricts evidence to what existed then, which keeps later outcomes out of the reading and sharply improves what is retrieved.",
      "title": "As Of",
      "type": "integer"
    }
  },
  "required": [
    "claim"
  ],
  "title": "evaluate_claimArguments"
}

{
  "type": "object",
  "properties": {
    "result": {
      "title": "Result",
      "type": "string"
    }
  },
  "required": [
    "result"
  ],
  "title": "evaluate_claimOutput"
}

Scope a scientific, biomedical, clinical, or AI/ML claim for evaluation. Returns three things: the source catalog, meaning where the evidence for this claim class lives; the diligence apparatus for that class, meaning the questions a domain reviewer asks and the failure patterns that have caught comparable claims before; and the scoping rubric used to work out which evidence dimensions bear on this particular claim and what to search for. Applies to a research claim, a study, a paper, an abstract, a preprint, a grant or a pitch, and to checking a paper or statistic before relying on it. Runs no model, costs nothing, and returns immediately. The queries worked out from its output are what zetesis_evidence takes as input. With as_of set, the apparatus and rubric are framed for judging the claim as it stood at the end of that year. Args: claim: the claim to evaluate, in one or two sentences. context: optional background (stage, field, the decision at hand). as_of: optional year. Set it to evaluate the claim as it stood at the end of that year, grading how it was derived at the time rather than how it turned out. claim_class: optional override for the routed claim class. The response lists every class; pass one back if the routing picked wrongly, or if nothing routed.

{
  "type": "object",
  "properties": {
    "claim": {
      "description": "The claim to evaluate, in one or two sentences.",
      "title": "Claim",
      "type": "string"
    },
    "context": {
      "default": "",
      "description": "Optional background: stage, field, or the decision at hand.",
      "title": "Context",
      "type": "string"
    },
    "as_of": {
      "default": 0,
      "description": "Year the claim was made. Set it for any claim that is not brand new: it restricts evidence to what existed then, which keeps later outcomes out of the reading and sharply improves what is retrieved.",
      "title": "As Of",
      "type": "integer"
    },
    "claim_class": {
      "default": "",
      "description": "Optional override for the routed claim class. The response lists every class; pass one back if the routing picked wrongly.",
      "title": "Claim Class",
      "type": "string"
    }
  },
  "required": [
    "claim"
  ],
  "title": "zetesis_scopeArguments"
}

{
  "type": "object",
  "properties": {
    "result": {
      "title": "Result",
      "type": "string"
    }
  },
  "required": [
    "result"
  ],
  "title": "zetesis_scopeOutput"
}

Step 2 of a Zetesis evaluation. Runs the search queries against public evidence sources (Europe PMC, ClinicalTrials.gov, openFDA, and optionally NIH RePORTER and SEC EDGAR) and returns a deduplicated bundle where every source carries a hard public id, followed by the Zetesis grading rubric so you can grade the dimensions yourself. With as_of set, retrieval is fenced to sources published, registered, or filed on or before 31 December of that year, and two fields that leak later outcomes are suppressed: a trial's present-day status, and FDA labels effective after the cutoff. That makes it possible to judge a claim on what was actually knowable at the time. Runs no model, costs nothing, and returns immediately. Takes the queries worked out when the claim was scoped. Args: queries: 3 to 6 short keyword phrases. Query 1 should be the bare name of the thing claimed about (a drug, compound code, model, or gene); query 2 that name plus at most two outcome words. Longer phrases retrieve commentary rather than the primary report. If the claim names no agent at all (a behaviour, diet, procedure, exposure or policy), anchor on the field's own technical term instead of the lay one ("time restricted eating", not "intermittent fasting"), pair it with the outcome as the field measures it, and allow one design word such as crossover or randomized in one later query. Without an entity name that design word is the only thing separating a trial report from a review of trial reports. as_of: optional cutoff year, as used in zetesis_scope. include_capital: also retrieve funding and public-filing signal.

{
  "type": "object",
  "properties": {
    "queries": {
      "description": "Three to six short keyword phrases. Query 1 should be the bare name of the thing claimed about; query 2 that name plus at most two outcome words.",
      "items": {
        "type": "string"
      },
      "title": "Queries",
      "type": "array"
    },
    "as_of": {
      "default": 0,
      "description": "Year the claim was made. Set it for any claim that is not brand new: it restricts evidence to what existed then, which keeps later outcomes out of the reading and sharply improves what is retrieved.",
      "title": "As Of",
      "type": "integer"
    },
    "include_capital": {
      "default": false,
      "description": "Also retrieve funding and public filing signal from NIH RePORTER and SEC EDGAR.",
      "title": "Include Capital",
      "type": "boolean"
    }
  },
  "required": [
    "queries"
  ],
  "title": "zetesis_evidenceArguments"
}

{
  "type": "object",
  "properties": {
    "result": {
      "title": "Result",
      "type": "string"
    }
  },
  "required": [
    "result"
  ],
  "title": "zetesis_evidenceOutput"
}

Verify a Zetesis attestation, confirming an evaluation's claim, evidence, and conclusion have not been altered since it was signed. Use when someone has a Zetesis dossier or attestation and wants to independently re-check it. Args: attestation_json: the full attestation object as JSON text.

{
  "type": "object",
  "properties": {
    "attestation_json": {
      "description": "The full Zetesis attestation object, as JSON text.",
      "title": "Attestation Json",
      "type": "string"
    }
  },
  "required": [
    "attestation_json"
  ],
  "title": "verify_attestationArguments"
}

{
  "type": "object",
  "properties": {
    "result": {
      "title": "Result",
      "type": "string"
    }
  },
  "required": [
    "result"
  ],
  "title": "verify_attestationOutput"
}