MCP MeasureMCP Measure

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ivive.app

Human hepatic clearance from in-vitro CLint, with the error band measured on known drugs.

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Calidad y seguridad

A
Calidad de la descripción
93%
Integridad del esquema
86%
Calidad de los nombres
80%
Riesgo de envenenamiento
100%
Coincidencia de permisos
100%
Cumplimiento del protocolo
100%

Basado en el análisis automatizado de las definiciones de herramientas y el cumplimiento del protocolo.

Costo de contexto

~2,172Tokens (definiciones de herramientas)
~3.6 KBTamaño de respuesta típico
Impacto moderado en la atención (1.70% del contexto de 128k)

Este es el número aproximado de tokens que se consumen cada vez que las herramientas del servidor se cargan en el contexto de un modelo. Los recuentos más altos reducen la atención disponible para otras tareas.

Instalar

Instalación con un clic

Agrega esto a tu archivo `claude_desktop_config.json`:

{
  "mcpServers": {
    "ivive": {
      "url": "https://api.ivive.app/mcp/"
    }
  }
}

Puntos de conexión remotos

https://api.ivive.app/mcp/streamable-http

Qué puede hacer

Inventario de herramientas

Herramientas (6)

🟢 Solo lectura🟡 Escritura🔴 Eliminación⚪ Desconocido
🟢predict_inputs(smiles, assay_type, concentration)

Predict fu,p and fu,inc from a SMILES, with structure-only human CL and Vss as second opinions. Predictions, not measurements; check the applicability verdict.

Esquema de entrada

{
  "type": "object",
  "properties": {
    "smiles": {
      "maxLength": 2000,
      "title": "Smiles",
      "type": "string"
    },
    "assay_type": {
      "default": "microsomes",
      "enum": [
        "microsomes",
        "hepatocytes"
      ],
      "title": "Assay Type",
      "type": "string"
    },
    "concentration": {
      "default": 1,
      "description": "Incubation concentration: mg microsomal protein/mL, or 10⁶ hepatocytes/mL.",
      "exclusiveMinimum": 0,
      "maximum": 10,
      "title": "Concentration",
      "type": "number"
    }
  },
  "required": [
    "smiles"
  ],
  "title": "PredictionRequest"
}
⚪calc_clhep(clint, fu_mic, fu_p, rb, species, ...)

Hepatic and plasma clearance from in-vitro CLint, fu,mic and fu,p (IVIVE), with the observed-CL band and applicability warnings. If fu,p or fu,mic came from predict_inputs, tell the user the result rests on predicted inputs.

Esquema de entrada

{
  "type": "object",
  "properties": {
    "clint": {
      "description": "Intrinsic clearance (µL/min/mg microsomal protein). Use ge=0: zero clearance is physiologically valid.",
      "minimum": 0,
      "title": "Clint",
      "type": "number"
    },
    "fu_mic": {
      "description": "Unbound fraction in microsomes (0–1). Corrects for non-specific microsomal binding.",
      "exclusiveMinimum": 0,
      "maximum": 1,
      "title": "Fu Mic",
      "type": "number"
    },
    "fu_p": {
      "description": "Unbound fraction in plasma (0–1). Plasma protein binding correction.",
      "maximum": 1,
      "minimum": 0,
      "title": "Fu P",
      "type": "number"
    },
    "rb": {
      "default": 1,
      "description": "Blood-to-plasma concentration ratio. fu_b = fu_p / Rb. Output is blood clearance.",
      "exclusiveMinimum": 0,
      "maximum": 50,
      "title": "Rb",
      "type": "number"
    },
    "species": {
      "description": "Species for physiological parameters (Qh, MPPGL, liver weight).",
      "enum": [
        "human",
        "rat",
        "dog"
      ],
      "title": "Species",
      "type": "string"
    },
    "model": {
      "default": "well-stirred",
      "description": "IVIVE model. well-stirred (venous equilibrium) or parallel-tube (sinusoidal perfusion).",
      "enum": [
        "well-stirred",
        "parallel-tube"
      ],
      "title": "Model",
      "type": "string"
    },
    "assay_type": {
      "default": "microsomes",
      "description": "Assay type for CLint scaling. microsomes: uses MPPGL (mg/g) × 1e-3; hepatocytes: uses HPGL (×10⁶ cells/g) × 1e-3.",
      "enum": [
        "microsomes",
        "hepatocytes"
      ],
      "title": "Assay Type",
      "type": "string"
    },
    "correction_id": {
      "anyOf": [
        {
          "format": "uuid",
          "type": "string"
        },
        {
          "type": "null"
        }
      ],
      "default": null,
      "description": "Saved lab correction (/api/correction-equations) to apply. Must match species and assay_type. Corrects predicted plasma CL and replaces the reference band with one from the lab's compounds.",
      "title": "Correction Id"
    },
    "clint_censored": {
      "default": false,
      "description": "Set when the assay reported CLint below its limit of quantification and `clint` is that limit rather than a measurement. CLint then lies in [0, clint), so every clearance output is an upper bound: `upper_bound` is true, no observed-CL band is returned, and the clint_below_loq flag fires.",
      "title": "Clint Censored",
      "type": "boolean"
    }
  },
  "required": [
    "clint",
    "fu_mic",
    "fu_p",
    "species"
  ],
  "title": "CLhepRequest"
}
🟢target_clint(target_clp, fu_mic, fu_p, rb, species, ...)

The in-vitro CLint an assay must read for a compound to reach a target plasma clearance.

Esquema de entrada

{
  "type": "object",
  "properties": {
    "target_clp": {
      "description": "Plasma clearance to aim for (mL/min/kg). Must be below hepatic blood flow × Rb.",
      "exclusiveMinimum": 0,
      "title": "Target Clp",
      "type": "number"
    },
    "fu_mic": {
      "exclusiveMinimum": 0,
      "maximum": 1,
      "title": "Fu Mic",
      "type": "number"
    },
    "fu_p": {
      "exclusiveMinimum": 0,
      "maximum": 1,
      "title": "Fu P",
      "type": "number"
    },
    "rb": {
      "default": 1,
      "exclusiveMinimum": 0,
      "maximum": 50,
      "title": "Rb",
      "type": "number"
    },
    "species": {
      "enum": [
        "human",
        "rat",
        "dog"
      ],
      "title": "Species",
      "type": "string"
    },
    "model": {
      "default": "well-stirred",
      "enum": [
        "well-stirred",
        "parallel-tube"
      ],
      "title": "Model",
      "type": "string"
    },
    "assay_type": {
      "default": "microsomes",
      "enum": [
        "microsomes",
        "hepatocytes"
      ],
      "title": "Assay Type",
      "type": "string"
    }
  },
  "required": [
    "target_clp",
    "fu_mic",
    "fu_p",
    "species"
  ],
  "title": "TargetClintRequest"
}
⚪input_sensitivity(clint, fu_mic, fu_p, rb, species, ...)

How far plasma CL moves as each input is varied over a range, e.g. a predicted fu,p over its 50% range.

Esquema de entrada

{
  "type": "object",
  "properties": {
    "clint": {
      "description": "Intrinsic clearance (µL/min/mg microsomal protein). Use ge=0: zero clearance is physiologically valid.",
      "minimum": 0,
      "title": "Clint",
      "type": "number"
    },
    "fu_mic": {
      "description": "Unbound fraction in microsomes (0–1). Corrects for non-specific microsomal binding.",
      "exclusiveMinimum": 0,
      "maximum": 1,
      "title": "Fu Mic",
      "type": "number"
    },
    "fu_p": {
      "description": "Unbound fraction in plasma (0–1). Plasma protein binding correction.",
      "maximum": 1,
      "minimum": 0,
      "title": "Fu P",
      "type": "number"
    },
    "rb": {
      "default": 1,
      "description": "Blood-to-plasma concentration ratio. fu_b = fu_p / Rb. Output is blood clearance.",
      "exclusiveMinimum": 0,
      "maximum": 50,
      "title": "Rb",
      "type": "number"
    },
    "species": {
      "description": "Species for physiological parameters (Qh, MPPGL, liver weight).",
      "enum": [
        "human",
        "rat",
        "dog"
      ],
      "title": "Species",
      "type": "string"
    },
    "model": {
      "default": "well-stirred",
      "description": "IVIVE model. well-stirred (venous equilibrium) or parallel-tube (sinusoidal perfusion).",
      "enum": [
        "well-stirred",
        "parallel-tube"
      ],
      "title": "Model",
      "type": "string"
    },
    "assay_type": {
      "default": "microsomes",
      "description": "Assay type for CLint scaling. microsomes: uses MPPGL (mg/g) × 1e-3; hepatocytes: uses HPGL (×10⁶ cells/g) × 1e-3.",
      "enum": [
        "microsomes",
        "hepatocytes"
      ],
      "title": "Assay Type",
      "type": "string"
    },
    "correction_id": {
      "anyOf": [
        {
          "format": "uuid",
          "type": "string"
        },
        {
          "type": "null"
        }
      ],
      "default": null,
      "description": "Saved lab correction (/api/correction-equations) to apply. Must match species and assay_type. Corrects predicted plasma CL and replaces the reference band with one from the lab's compounds.",
      "title": "Correction Id"
    },
    "clint_censored": {
      "default": false,
      "description": "Set when the assay reported CLint below its limit of quantification and `clint` is that limit rather than a measurement. CLint then lies in [0, clint), so every clearance output is an upper bound: `upper_bound` is true, no observed-CL band is returned, and the clint_below_loq flag fires.",
      "title": "Clint Censored",
      "type": "boolean"
    },
    "clint_range": {
      "anyOf": [
        {
          "$ref": "#/$defs/InputRange"
        },
        {
          "type": "null"
        }
      ],
      "default": null
    },
    "fu_mic_range": {
      "anyOf": [
        {
          "$ref": "#/$defs/InputRange"
        },
        {
          "type": "null"
        }
      ],
      "default": null
    },
    "fu_p_range": {
      "anyOf": [
        {
          "$ref": "#/$defs/InputRange"
        },
        {
          "type": "null"
        }
      ],
      "default": null,
      "description": "A predicted fu,p carries its 50% range; pass it to see what it costs."
    }
  },
  "required": [
    "clint",
    "fu_mic",
    "fu_p",
    "species"
  ],
  "$defs": {
    "InputRange": {
      "properties": {
        "low": {
          "exclusiveMinimum": 0,
          "title": "Low",
          "type": "number"
        },
        "high": {
          "exclusiveMinimum": 0,
          "title": "High",
          "type": "number"
        }
      },
      "required": [
        "low",
        "high"
      ],
      "title": "InputRange",
      "type": "object"
    }
  },
  "description": "The same inputs as a calculation, plus the range to vary each over.",
  "title": "SensitivityRequest"
}
⚪similar_drugs(smiles, n)

Most similar reference drugs to a SMILES, with observed and IVIVE-predicted clearance: how IVIVE fared on this kind of structure.

Esquema de entrada

{
  "type": "object",
  "properties": {
    "smiles": {
      "maxLength": 2000,
      "title": "Smiles",
      "type": "string"
    },
    "n": {
      "default": 3,
      "maximum": 10,
      "minimum": 1,
      "title": "N",
      "type": "integer"
    }
  },
  "required": [
    "smiles"
  ],
  "title": "SimilarityRequest"
}
⚪scale_to_human(animals, fu_p_human)

Predict human plasma CL from observed animal in-vivo CL (rat, dog, monkey), every applicable method with its measured error. Observed animal CL only, never predicted.

Esquema de entrada

{
  "type": "object",
  "properties": {
    "animals": {
      "items": {
        "$ref": "#/$defs/SpeciesPoint"
      },
      "minItems": 1,
      "title": "Animals",
      "type": "array"
    },
    "fu_p_human": {
      "anyOf": [
        {
          "exclusiveMinimum": 0,
          "maximum": 1,
          "type": "number"
        },
        {
          "type": "null"
        }
      ],
      "default": null,
      "description": "Human unbound fraction, needed by the fu-corrected methods",
      "title": "Fu P Human"
    }
  },
  "required": [
    "animals"
  ],
  "$defs": {
    "SpeciesPoint": {
      "description": "One animal's measured in-vivo plasma clearance, and optionally its binding.",
      "properties": {
        "species": {
          "description": "One of ['dog', 'monkey', 'rat']",
          "title": "Species",
          "type": "string"
        },
        "cl": {
          "description": "Observed plasma CL, mL/min/kg",
          "exclusiveMinimum": 0,
          "maximum": 1000,
          "title": "Cl",
          "type": "number"
        },
        "fu_p": {
          "anyOf": [
            {
              "exclusiveMinimum": 0,
              "maximum": 1,
              "type": "number"
            },
            {
              "type": "null"
            }
          ],
          "default": null,
          "description": "Unbound fraction in plasma for this species",
          "title": "Fu P"
        }
      },
      "required": [
        "species",
        "cl"
      ],
      "title": "SpeciesPoint",
      "type": "object"
    }
  },
  "title": "ScalingRequest"
}

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